Local injection of endothelin-1 produces pain-like behavior and excitation of nociceptors in rats.

@article{Gokin2001LocalIO,
  title={Local injection of endothelin-1 produces pain-like behavior and excitation of nociceptors in rats.},
  author={Alex P Gokin and Moin U Fareed and H L Pan and Gr{\'e}gory A Hans and Gary R. Strichartz and Gudarz Davar},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2001},
  volume={21 14},
  pages={5358-66}
}
Neurobehavioral and neurophysiological actions of the peptide endothelin-1 (ET-1) were investigated after subcutaneous plantar hindpaw injections in adult male Sprague Dawley rats. Hindpaw flinching developed within minutes after ET-1 (8-16 nmol) injection, peaked at 30 min, lasted for 60 min, and was strongly inhibited by the endothelin-A (ET(A)) receptor antagonist, BQ-123 (3.2 m). In separate experiments, impulse activity of single, physiologically characterized sensory C-, Adelta-, and… CONTINUE READING
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