Local inhibition of angiotensin II formation and bradykinin degradation in isolated hearts.

Abstract

The interaction of the converting enzyme (CE)-inhibitor ramipril and the bradykinin (BK)-antagonist D-Arg-[Hyp2, Thi5,8, D-Phe7]BK with angiotensin I (ANG), ANG II and BK were studied in isolated hearts of rats and guinea pigs. In isolated working rat hearts perfusion with ANG I and ANG II reduced cardiac function and coronary flow, increased the activities… (More)

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Cite this paper

@article{Schlkens1988LocalIO, title={Local inhibition of angiotensin II formation and bradykinin degradation in isolated hearts.}, author={Bernward A. Sch{\"{o}lkens and Wolfgang J. Linz}, journal={Clinical and experimental hypertension. Part A, Theory and practice}, year={1988}, volume={10 6}, pages={1259-70} }