Local inflammatory markers and systemic endotoxin in aggressive periodontitis.

  title={Local inflammatory markers and systemic endotoxin in aggressive periodontitis.},
  author={Luciana M Shaddox and J Wiedey and Nadia L Calderon and Ingvar Magnusson and Enrique Bimstein and John A Bidwell and Edward F Zapert and Ikramuddin Aukhil and Shannon Margaret Wallet},
  journal={Journal of dental research},
  volume={90 9},
While much research has focused on local and systemic factors contributing to periodontal disease, little is known regarding mechanisms linking these factors. We have previously reported a systemic hyper-inflammatory response to bacterial endotoxin in localized aggressive periodontitis (LAP). The objectives of this study were to delineate cyto/chemokines in gingival crevicular fluid (GCF) and evaluate systemic levels of endotoxin associated with LAP. Clinical parameters, GCF, and peripheral… CONTINUE READING