Local immunoglobulin production in nasal polyposis is modulated by superantigens.

  title={Local immunoglobulin production in nasal polyposis is modulated by superantigens.},
  author={Thibaut P J van Zele and P Gevaert and Gabriele Holtappels and Paul van Cauwenberge and Claus Bachert},
  journal={Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology},
  volume={37 12},
BACKGROUND Chronic rhinosinusitis (CRS) with nasal polyps (NP) represents a persistent inflammation often characterized by local hyper-immunoglobulinaemia and the presence of specific IgE to Staphylococcus aureus enterotoxins (SAEs). We aimed to study the systemic and local production of Igs in relation to plasma cells, B cells and specific IgE to SAEs. METHODS Concentrations of IgE, IgG, IgM, IgA, IgG subclasses and specific IgE to SAE were determined on tissue homogenates and serum from 15… CONTINUE READING


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