Local immune response and bronchial reactivity in rats after capsaicin treatment

  title={Local immune response and bronchial reactivity in rats after capsaicin treatment},
  author={Gunnar P Nilsson and Kjell Alving and Jan M. Lundberg and Staffan Ahlstedt},
The interaction between the nervous system, immune system and bronchial reactivity was studied in rat by using the neurotoxin capsaicin. Rats were treated with capsaicin at 1‐2 days of age or at adult age, before or after sensitization by subcutaneous injections with ovalbumin (OA). The levels of the neuropeptides neurokinin A and calcitonin gene‐related peptide were decreased in the lung after capsaicin treatment, as determined with radioimmunoassay, whereas the levels of neuropeptide Y were… 

Sensory denervation by neonatal capsaicin treatment exacerbates Mycoplasma pulmonis infection in rat airways.

It is concluded that destruction of sensory nerves increases the severity of infection- induced chronic inflammation in the airway mucosa, with exaggerated mucosal thickening, angiogenesis, plasma leakage, and nerve remodeling.

Hyperinnervation of the airways in transgenic mice overexpressing nerve growth factor.

It is concluded that NGF overexpression from a lung-specific promoter produces anatomic and functional changes in lung innervation, and that CCSP-NGF mice will be useful for studying the role of neurogenic inflammation in airway disease.

Capsaicin inhibits Jurkat T-cell activation by blocking calcium entry current I(CRAC).

It is shown that capsaicin, the pungent ingredient of hot chili pepper, blocks receptor-stimulated Ca2+ entry in Jurkat T cells and its numerous analogs may have potential use as immunomodulatory drugs and should be further investigated in models of inflammation and T-cell activation.



Enhancement of the bronchial reactivity in immunized rats by neonatal treatment with capsaicin.

Histologically, the animals treated with capsaicin in contrast to the untreated controls demonstrated a pronounced increase of lymphoid tissue around their bronchi and bronchioli, and the sensitization did not add much to this histological picture.

The effect of substance P on the regional lymph node antibody response to antigenic stimulation in capsaicin-pretreated rats.

The results suggest that the reduced response of capsaicin-treated animals to an antigenic stimulus is due to an effect of Capsaicin on the SP-containing primary afferent nerves rather than a toxic effect of capsicin onThe immune system.

Altered lymphocyte proliferation of immunized rats after neurological manipulation with capsaicin.

Capsaicin and histamine antagonist-sensitive mechanisms in the immediate allergic reaction of pig airways.

It is concluded that histamine is one of the main vasodilatory mediators released upon allergen challenge at three different levels of the pig airways and probably due to activation of capsaicin-sensitive sensory nerves.

Capsaicin‐sensitive nerves and the cutaneous allergy reaction in man

It is concluded that capsaicin sensitive sensory nerves are of importance for the human cutaneous triple response reaction induced by allergen exposure and secondary release of mediators, such as CGRP or tachykinins from sensory nerve branches, may contribute to the flare component of this reaction.

Neuropeptides and the pathogenesis of allergy

Following the discovery of histamine at the turn of this century. Dale and his associates were quick to note the parallel between the effects of histamine in animals and the manifestations of an

Immune Stimulated Regional Inflammatory Responses Mediating Lung Reactivity in Rats

Daily sensitization of SPF BNxWi/Fu rats with ovalbumin (OA) in aerosol during 2‐week periods with a 4‐week interval resulted after 7 weeks in IgE, IgA and IgG antibodies in serum and bronchial

Direct evidence for neurogenic inflammation and its prevention by denervation and by pretreatment with capsaicin.

The question of the role played by the sensory nerves in the mechanism of the inflammatory response arose at the beginning of this century and was almost entirely neglected in modem research and experimental work has been confined mainly to the study of axon reflex flare in human skin.