Local immune response and bronchial reactivity in rats after capsaicin treatment

@article{Nilsson1991LocalIR,
  title={Local immune response and bronchial reactivity in rats after capsaicin treatment},
  author={Gunnar P Nilsson and Kjell Alving and Jan M. Lundberg and Staffan Ahlstedt},
  journal={Allergy},
  year={1991},
  volume={46}
}
The interaction between the nervous system, immune system and bronchial reactivity was studied in rat by using the neurotoxin capsaicin. Rats were treated with capsaicin at 1‐2 days of age or at adult age, before or after sensitization by subcutaneous injections with ovalbumin (OA). The levels of the neuropeptides neurokinin A and calcitonin gene‐related peptide were decreased in the lung after capsaicin treatment, as determined with radioimmunoassay, whereas the levels of neuropeptide Y were… 

Sensory denervation by neonatal capsaicin treatment exacerbates Mycoplasma pulmonis infection in rat airways.

It is concluded that destruction of sensory nerves increases the severity of infection- induced chronic inflammation in the airway mucosa, with exaggerated mucosal thickening, angiogenesis, plasma leakage, and nerve remodeling.

Hyperinnervation of the airways in transgenic mice overexpressing nerve growth factor.

It is concluded that NGF overexpression from a lung-specific promoter produces anatomic and functional changes in lung innervation, and that CCSP-NGF mice will be useful for studying the role of neurogenic inflammation in airway disease.

Capsaicin inhibits Jurkat T-cell activation by blocking calcium entry current I(CRAC).

It is shown that capsaicin, the pungent ingredient of hot chili pepper, blocks receptor-stimulated Ca2+ entry in Jurkat T cells and its numerous analogs may have potential use as immunomodulatory drugs and should be further investigated in models of inflammation and T-cell activation.

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