Local generation of angiotensin II as a mechanism of regulation of peripheral vascular tone in the rat.

@article{Oliver1984LocalGO,
  title={Local generation of angiotensin II as a mechanism of regulation of peripheral vascular tone in the rat.},
  author={Juan A. Oliver and Robert R. Sciacca},
  journal={The Journal of clinical investigation},
  year={1984},
  volume={74 4},
  pages={1247-51}
}
Renin is present in vascular smooth muscle cells and has been shown to coexist with angiotensins I (AI) and II (AII) in many cell types. Accordingly, we postulated that the renin-angiotensin system controls vascular tone, not by the action of circulating renal renin but rather, by the local generation of angiotensin by vascular renin. Isolated rat hindquarters were perfused in vitro with Krebs-Henseleit buffer containing 7% albumin, and flow-adjusted to obtain a perfusion pressure of… CONTINUE READING