Local gene delivery of recombinant adenoviruses to the rat carotid artery in vivo.

A number of animal models are available to investigators wishing to study the use of gene transfer to prevent neointimal formation after vascular injury. The majority are models of primary vascular injury rather than the human situation, where recurrence of a stenosis occurs in an abnormal blood vessel treated by angioplasty. The main animal models used to… (More)