Local expression of mIgf-1 modulates ubiquitin, caspase and CDK5 expression in skeletal muscle of an ALS mouse model.

@article{Dobrowolny2008LocalEO,
  title={Local expression of mIgf-1 modulates ubiquitin, caspase and CDK5 expression in skeletal muscle of an ALS mouse model.},
  author={Gabriella Dobrowolny and Michela Aucello and Mario Molinaro and Antonio Musar{\`o}},
  journal={Neurological research},
  year={2008},
  volume={30 2},
  pages={
          131-6
        }
}
OBJECTIVE The functional connection between muscle and nerve is often altered in several neuromuscular diseases, including amyotrophic lateral sclerosis (ALS). Knowledge about the molecular and cellular mechanisms involved in the restorative reactions is important to our understanding of the processes involved in neuromuscular maintenance. We previously reported that muscle-restricted expression of a localized Igf-1 isoform maintained muscle integrity, stabilized neuromuscular junctions… CONTINUE READING
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