Local expression of GH and IGF-1 in the hippocampus of GH-deficient long-lived mice.

@article{Sun2005LocalEO,
  title={Local expression of GH and IGF-1 in the hippocampus of GH-deficient long-lived mice.},
  author={Liou Y Sun and Khalid A Al-Regaiey and Michal M. Masternak and Jian Wang and Andrzej Bartke},
  journal={Neurobiology of aging},
  year={2005},
  volume={26 6},
  pages={929-37}
}
Beneficial effects of growth hormone (GH) and insulin-like growth factor-1 (IGF-1) on the development and function of the central nervous system are well documented. In spite of primary deficiency of GH and secondary IGF-1 deficiency, Ames dwarf mice live considerably longer than normal animals, exhibit apparently normal cognitive functions and maintain them into advanced age. In an attempt to reconcile these findings, we have examined local expression of GH and IGF-1 in the hippocampus of… CONTINUE READING