Local expression of C-type natriuretic peptide suppresses inflammation, eliminates shear stress-induced thrombosis, and prevents neointima formation through enhanced nitric oxide production in rabbit injured carotid arteries.

@article{Qian2002LocalEO,
  title={Local expression of C-type natriuretic peptide suppresses inflammation, eliminates shear stress-induced thrombosis, and prevents neointima formation through enhanced nitric oxide production in rabbit injured carotid arteries.},
  author={Jian-Yong Qian and Akihiro Haruno and Yujiro Asada and Takahiro Nishida and Yasushi Saito and Takehisa Matsuda and Hikaru Ueno},
  journal={Circulation research},
  year={2002},
  volume={91 11},
  pages={1063-9}
}
We previously observed that adenovirus-mediated expression of C-type natriuretic peptide (CNP) markedly inhibits neointima formation after balloon injury in rat carotid arteries, suggesting that CNP has multiple effects over its modest inhibitory effect on cellular proliferation. We hypothesized that local expression of CNP might have antithrombotic and antiinflammatory effects. Balloon-injured rabbit carotid arteries were infected with an adenovirus expressing human CNP (AdCNP), human tissue… CONTINUE READING
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