Local exposure of bone components to injured soft tissue induces Toll-like receptor 4-dependent systemic inflammation with acute lung injury.

@article{Kobbe2008LocalEO,
  title={Local exposure of bone components to injured soft tissue induces Toll-like receptor 4-dependent systemic inflammation with acute lung injury.},
  author={Philipp Kobbe and David J Kaczorowski and Yoram Vodovotz and Christopher H Tzioupis and Kevin P. Mollen and Timothy R Billiar and H. -Ch. Pape},
  journal={Shock},
  year={2008},
  volume={30 6},
  pages={686-91}
}
Remote and systemic inflammatory responses after long bone fractures have been well described, but the mechanisms underlying these changes remain unexplained. We hypothesized that bone components locally exposed to injured soft tissue are capable of inducing a systemic inflammatory response associated with acute lung injury, and that this inflammatory cascade requires Toll-like receptor 4 (TLR-4) signaling. Accordingly, male C3H/HeOuJ (TLR-4-competent) and C3H/HeJ (TLR-4-mutant) mice were… CONTINUE READING
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