Local estrogen therapy and risk of breast cancer recurrence among hormone-treated patients: a nested case–control study

@article{Ray2012LocalET,
  title={Local estrogen therapy and risk of breast cancer recurrence among hormone-treated patients: a nested case–control study},
  author={Isabelle Le Ray and Sophie Dell’Aniello and Franck Bonnetain and Laurent Azoulay and Samy Suissa},
  journal={Breast Cancer Research and Treatment},
  year={2012},
  volume={135},
  pages={603-609}
}
Women with estrogen-positive breast cancers receive endocrine treatment such as tamoxifen and aromatase inhibitors (AI) for 5–10 years. An important side effect of these drugs is vaginal dryness for which local hormonal therapy (LHT) represents the most effective treatment but is theoretically contraindicated. This study aimed to assess whether the use of LHT increases the risk of breast cancer recurrence among women receiving endocrine treatment. We conducted a cohort study with nested case… CONTINUE READING
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