Local estrogen biosynthesis in males and females.

@article{Simpson1999LocalEB,
  title={Local estrogen biosynthesis in males and females.},
  author={Evan R. Simpson and Gary Rubin and Colin Clyne and Kirsten M. Robertson and Liza O’Donnell and Simon J. Davis and Margaret H. Jones},
  journal={Endocrine-related cancer},
  year={1999},
  volume={6 2},
  pages={
          131-7
        }
}
It is now apparent that in men and in postmenopausal women, estrogens have important physiological and pathophysiological roles. However, importantly, these actions are at a local level, namely paracrine, autocrine, and even 'intracrine' rather than endocrine in the classical sense. Thus for example local estrogen biosynthesis in the bones of men plays a hitherto unsuspected role in the maintenance of bone mineralization and in epiphyseal fusion; and in the testes, estrogen is essential for… CONTINUE READING

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