Local effect of tramadol on formalin evoked flinching behavior in rats.

@article{Sousa2008LocalEO,
  title={Local effect of tramadol on formalin evoked flinching behavior in rats.},
  author={{\^A}ngela Sousa and Paula Andrea Baptista Franco and Hazem Adel Ashmawi and Irimar de Paula Posso},
  journal={Revista brasileira de anestesiologia},
  year={2008},
  volume={58 4},
  pages={371-9}
}
BACKGROUND AND OBJECTIVES Tramadol hydrochloride is known as a centrally acting analgesic drug, used for the treatment of moderate to severe pain. A local analgesic effect has been demonstrated, but its mechanism of action remains unclear. METHODS In this study, we examined the effect of local, systemic and nerve block tramadol on the nociceptive… CONTINUE READING