Local effect of adenosine 5'-triphosphate on indomethacin-induced permeability changes in the human small intestine.


BACKGROUND Nonsteroidal anti-inflammatory drug (NSAID) use is associated with an elevated risk of gastrointestinal damage. As adenosine 5'-triphosphate (ATP) may play a protective role in the small intestine, our objective was to determine the local effect of ATP on small intestinal permeability changes induced by short-term challenge of the NSAID… (More)