Local drug delivery for treatment of coronary and peripheral artery disease.

  title={Local drug delivery for treatment of coronary and peripheral artery disease.},
  author={Zachary M. Gertz and Robert L. Wilensky},
  journal={Cardiovascular therapeutics},
  volume={29 6},
Local drug delivery (LDD), the direct application of a therapeutic agent to a focal location, has been used in cardiovascular interventions to prophylactically reduce neointimal hyperplasia and relieve clot burden. LDD allows targeted use of drugs whose toxicities inhibit their systemic use while stent delivery allows for consistent and prolonged delivery. Stents eluting limus family drugs or paclitaxel inhibit vascular smooth muscle cell hyperplasia and migration and clinical use of such… CONTINUE READING


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