Local delivery of the KCa3.1 blocker, TRAM-34, prevents acute angioplasty-induced coronary smooth muscle phenotypic modulation and limits stenosis.

@article{Tharp2008LocalDO,
  title={Local delivery of the KCa3.1 blocker, TRAM-34, prevents acute angioplasty-induced coronary smooth muscle phenotypic modulation and limits stenosis.},
  author={Darla L. Tharp and Brian R. Wamhoff and Heike Wulff and Girija Raman and Ana Cheong and Douglas K. Bowles},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2008},
  volume={28 6},
  pages={1084-9}
}
OBJECTIVE We previously demonstrated that upregulation of intermediate-conductance Ca(2+)-activated K(+) channels (K(Ca)3.1) is necessary for mitogen-induced phenotypic modulation in isolated porcine coronary smooth muscle cells (SMCs). The objective of the present study was to determine the role of K(Ca)3.1 in the regulation of coronary SMC phenotypic modulation in vivo using a swine model of postangioplasty restenosis. METHODS AND RESULTS Balloon angioplasty was performed on coronary… CONTINUE READING
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