Local delivery of platelet-derived growth factor receptor-specific tyrphostin inhibits neointimal formation in rats.

@article{Fishbein2000LocalDO,
  title={Local delivery of platelet-derived growth factor receptor-specific tyrphostin inhibits neointimal formation in rats.},
  author={Ilia Fishbein and Johannes Waltenberger and Shmuel Banai and Laura Rabinovich and Michael Chorny and Alexander Levitzki and A Amatzia Gazit and Roman Huber and Ulrike Beate Mayr and S. David Gertz and Gershon Golomb},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2000},
  volume={20 3},
  pages={667-76}
}
Signal transduction through the platelet-derived growth factor (PDGF)/PDGF receptor (PDGFR) system is involved in the process of postangioplasty restenosis. Tyrphostins are low molecular weight inhibitors of protein tyrosine kinases. We assessed the antiproliferative effects of PDGFRbeta-specific tyrphostin AG-1295 in vitro and in vivo. AG-1295… CONTINUE READING