Local delivery of nicotine does not mitigate fibrosis but may lead to angiogenesis.

@article{Ng2011LocalDO,
  title={Local delivery of nicotine does not mitigate fibrosis but may lead to angiogenesis.},
  author={Kenneth K. W. Ng and Neven Awad and Michael A Brook and Alison C Holloway and Heather Sheardown},
  journal={Journal of biomaterials applications},
  year={2011},
  volume={26 3},
  pages={349-58}
}
As with most implanted biomaterials, the wound healing response following implantation of a silicone breast implant leads to the formation of a fibrotic capsule. This can result in capsular contracture, a painful complication that often necessitates the removal of implant. It is well established that nicotine and nicotinic agonists inhibit inflammatory… CONTINUE READING