Local delivery of angiotensin receptor blocker into the kidney ameliorates progression of experimental glomerulonephritis.

@article{Mahmood2006LocalDO,
  title={Local delivery of angiotensin receptor blocker into the kidney ameliorates progression of experimental glomerulonephritis.},
  author={Javed Mahmood and Fahima Khan and Shin-ichi Okada and Naoki Kumagai and Tetsuo Morioka and Takashi Oite},
  journal={Kidney international},
  year={2006},
  volume={70 9},
  pages={1591-8}
}
Intrarenally synthesized angiotensin II (Ang II) may be involved in the progression of glomerulonephritis, leading to irreversible glomerulosclerosis. There is increasing evidence that systemic angiotensin receptor blocker (ARB) treatment has beneficial effect on the prognosis of progressive glomerulonephritis and diabetic nephropathy. However, the cellular and molecular mechanisms behind this therapeutic effect of ARB remain unclear. In this study, we used a novel strategy of local ARB… CONTINUE READING

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