Local delivery of a synthetic endostatin fragment for the treatment of experimental gliomas.

@article{Pradilla2005LocalDO,
  title={Local delivery of a synthetic endostatin fragment for the treatment of experimental gliomas.},
  author={Gustavo Pradilla and Federico Giuseppe Legnani and Giovanna Petrangolini and Pierangelo Francescato and Francesco Chillemi and Betty M. Tyler and Sergio Gaini and Henry Brem and Alessandro Olivi and Francesco DiMeco},
  journal={Neurosurgery},
  year={2005},
  volume={57 5},
  pages={1032-40; discussion 1032-40}
}
OBJECTIVE Endostatin is an anti-angiogenic agent that blocks matrix-metalloproteinase-2 and inhibits endothelial cell proliferation. Currently, endostatin is available through recombinant technology, which limits its broader use. In this study, a synthetic endostatin fragment (EF) was analyzed to determine its anti-angiogenic properties when locally delivered by controlled-release polymers and to establish its effect as a treatment for experimental gliomas. METHODS Cytotoxicity of EF against… CONTINUE READING
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