Local delivery of a direct renin inhibitor into the kidney ameliorates progression of experimental glomerulonephritis

@article{Sato2012LocalDO,
  title={Local delivery of a direct renin inhibitor into the kidney ameliorates progression of experimental glomerulonephritis},
  author={Akira Sato and Hoglan Piao and Yukiko Nozawa and Tetsuo Morioka and Hiroshi Kawachi and Takashi Oite},
  journal={Clinical and Experimental Nephrology},
  year={2012},
  volume={16},
  pages={539-548}
}
BackgroundIncreasing evidence indicates that locally blocking renin–angiotensin system activity exerts a beneficial effect on glomerulonephritis (GN) progression leading to irreversible glomerulosclerosis. This is the first study on the pharmacological effect of the renal delivery of aliskiren, a direct renin inhibitor, in a progressive model of anti-Thy-1 GN.MethodsLocal blockade of renin activity was accomplished by subrenal capsular implantation of a collagen sponge with aliskiren. The… CONTINUE READING
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Nephrotic syndrome and abdominal arterial bruits in a young hypertensive patient: a case report.

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