Local corticosteroid application blocks transmission in normal nociceptive C‐fibres

  title={Local corticosteroid application blocks transmission in normal nociceptive C‐fibres},
  author={Arne Johansson and Jingxia Hao and Bengt H. Sj{\"o}lund},
  journal={Acta Anaesthesiologica Scandinavica},
The effect of a locally applied depot form of a corticosteroid on the electrical properties of nerves was investigated in an experimental model. The segmental transmission in electrically stimulated A‐fibres and in C‐fibres of the plantar nerve in the anaesthetized rat was utilized. A drop of methylprednisolone acetate or vehicle constituent was placed on the dissected plantar nerve proximal to the stimulating electrodes after recording control responses (A‐fibre volley in the sciatic nerve and… 

Effect of Local Methylprednisolone on Pain in a Nerve Injury Model: A Pilot Study

It is hypothesized that the corticosteroid acts by suppression of ectopic neural discharges from the injured nerve fibers, indicating that a neuropathic pain-like condition has developed.

Local corticosteroids and pain. A clinical and experimental study

Nerve blocks with corticosteroids were found to be not very effective as a long-term treatment for chronic pain and the results do not rule out that there may exist some subgroup(s) of patients in which block therapy may have a specific, long-lasting effect.

Mechanical Hypersensitivity, Sympathetic Sprouting, and Glial Activation Are Attenuated by Local Injection of Corticosteroid Near the Lumbar Ganglion in a Rat Model of Neuropathic Pain

A single injection of corticosteroid in the vicinity of the axotomized DRG can mimic many effects of systemic TA, mitigating behavioral and cellular abnormalities induced by spinal nerve ligation, providing a further rationale for the use of localized steroid injections clinically.

Long‐term local corticosteroid application does not influence nerve transmission or structure

The long‐term effects of a locally applied depot form of a corticosteroid on the electrical properties and structure of nerves were investigated in an animal experimental model.

Delay of neuropathic pain sensitization after application of dexamethasone-loaded implant in sciatic nerve-injured rats

It is demonstrated that the dexamethasone-loaded biodegradable implant suppresses allodynia development and peripheral neuroinflammation and can reduce the potential side effects associated with oral anti-inflammatory drugs.

Potential neurotoxic effect of dexamethasone used as adjuvant to local anesthetics during peripheral nerve blockade

Intraneural injections of lidocaine in combination with dexamethasone caused neurological deficits and severe pathohistological damage to nerve fibers in Wistar rats.

Pharmacology of Interventional Headache Management

It is essential to follow the PREEMPT onabotulinum toxin A injection protocols of fixed-site/fixed-dose or follow-the-pain to achieve maximum efficacy in chronic migraine.



Peripheral nerve stimulation suppression of C-fiber-evoked flexion reflex in rats. Part 1: Parameters of continuous stimulation.

A conditioning stimulation of different parameters delivered to a dissected skin nerve in the lightly anesthetized rat utilizing the size of a C-fiber-evoked flexion reflex as a measure of transmission from nociceptive afferent fibers in the spinal cord was performed.

Peripheral nerve stimulation suppression of C-fiber-evoked flexion reflex in rats. Part 2: Parameters of low-rate train stimulation of skin and muscle afferent nerves.

  • B. Sjölund
  • Biology, Medicine
    Journal of neurosurgery
  • 1988
Constant conditioning stimulation of skin and muscle nerves in the spinal cord of a lightly anesthetized rat was extended to include short trains of stimuli at a low repetition rate, finding that stimulation of a muscle nerve was usually more effective in suppressing transmission from C-fibers to second-order neurons.

Corticosteroids: A direct effect at the neuromuscular junction

Data suggest that the early alterations and short-term fluctuations in myasthenic weakness seen in patients being treated with corticosteroids may be attributed at least in part to a direct effect on neuromuscular transmission.

Functional and topographical properties of field potentials evoked in rat dorsal horn by cutaneous C‐fibre stimulation.

Extracellular field potentials in the lumbosacral dorsal horn evoked by stimulation of cutaneous C fibres in the sural nerve were explored in the halothane‐anaesthetized rat and the potentiation was somatotopically organized.

Activity evoked by A- and C-afferent fibers in rat dorsal horn neurons and its relation to a flexion reflex.

The responses of 56 neurons recorded in the lumbosacral spinal cord of halothane-anesthetized rats were studied following the application of mechanical stimuli to the skin on the lateral aspect of the paw or electrical stimulation of the sural nerve to evaluate possible relations between neuronal events and reflex discharges.

Epidural Steroid Effects on Nerves and Meninges

It is concluded that local anesthetic-steroid combinations do not cause significant damage to neural tissues.

Glucocorticoid effects on central nervous excitability and synaptic transmission.

  • E. Hall
  • Biology, Medicine
    International review of neurobiology
  • 1982

Degenerative Lesions in Rat Sciatic Nerves After Local Injections of Methylprednisolone in Sterile Aqueous Suspension

Nerves treated with the methylprednisolone suspension and its sterile vehicle showed similar incidence and severity of patchy degenerative changes, including demyelination, axonal disorganization, and endoneurial collagen formation, suggesting that repeated injections of MPAS near a peripheral nerve may cause nerve damage.