Local control of nuclear calcium signaling in cardiac myocytes by perinuclear microdomains of sarcolemmal insulin-like growth factor 1 receptors.

@article{Ibarra2013LocalCO,
  title={Local control of nuclear calcium signaling in cardiac myocytes by perinuclear microdomains of sarcolemmal insulin-like growth factor 1 receptors.},
  author={Cristi{\'a}n Ibarra and Jos{\'e} Miguel Vicencio and Manuel Estrada and Yingbo Lin and Paola Rocco and Paola Rebellato and Juan Pablo Mu{\~n}oz and Jaime Garc{\'i}a-Prieto and Andrew F. G. Quest and Mario Chiong and Sean M. Davidson and Ivana Bulatovi{\'c} and Karl-Henrik Grinnemo and Olle Larsson and Gyorgy Szabadkai and Per Uhl{\'e}n and Enrique Jaimovich and Sergio Lavandero},
  journal={Circulation research},
  year={2013},
  volume={112 2},
  pages={
          236-45
        }
}
  • Cristián Ibarra, José Miguel Vicencio, +15 authors Sergio Lavandero
  • Published in Circulation research 2013
  • Biology, Medicine
  • RATIONALE The ability of a cell to independently regulate nuclear and cytosolic Ca(2+) signaling is currently attributed to the differential distribution of inositol 1,4,5-trisphosphate receptor channel isoforms in the nucleoplasmic versus the endoplasmic reticulum. In cardiac myocytes, T-tubules confer the necessary compartmentation of Ca(2+) signals, which allows sarcomere contraction in response to plasma membrane depolarization, but whether there is a similar structure tunneling… CONTINUE READING

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