Local control of inflammatory pain


The mechanism of the local hyperalgesic action of prostaglandin E2 has been studied using rat paw oedema. Prostaglandin E2 is a metabotropic transmitter, activating adenylate cyclase, either directly or through the release of a stimulatory protein factor. This activation of adenylatecyclase is blocked, locally, by opiates. Hyperalgesia results from the… (More)
DOI: 10.1007/BF01978773