Local control of Ca2+-induced Ca2+ release in mouse sinoatrial node cells.

@article{Chen2009LocalCO,
  title={Local control of Ca2+-induced Ca2+ release in mouse sinoatrial node cells.},
  author={Biyi Chen and Yuejin Wu and Peter J. Mohler and Mark E. Anderson and Long-sheng Song},
  journal={Journal of molecular and cellular cardiology},
  year={2009},
  volume={47 5},
  pages={706-15}
}
Emerging evidence from large animal models implicates Ca2+ regulation, particularly intracellular sarcoplasmic reticulum (SR) Ca2+ release, as essential for sinoatrial node (SAN) automaticity. However, despite the apparent importance of SR Ca2+ release to SAN cell function it is uncertain how SR Ca2+ release is controlled in SAN cells from mouse. Understanding mouse SAN SR Ca2+ release mechanism will allow improved understanding of results in studies on SAN from genetic mouse models of Ca2… CONTINUE READING

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