Corpus ID: 237266862

Local contact inhibition leads to universal principles of cell population growth

@inproceedings{Kimmel2021LocalCI,
  title={Local contact inhibition leads to universal principles of cell population growth},
  author={Gregory J. Kimmel and Jeffrey West and Mehdi Damaghi and Alexander R. A. Anderson and Philipp M. Altrock},
  year={2021}
}
Cancer cell population dynamics often exhibit remarkably replicable, universal laws despite their underlying heterogeneity. Mechanistic explanations of universal cell population growth remain partly unresolved to this day, whereby population feedback between the microscopic and mesoscopic configurations can lead to macroscopic growth laws. We here present a unification under density-dependent birth events via contact inhibition. We consider five classical tumor growth laws: exponential… Expand
1 Citations

Figures and Tables from this paper

Destabilization of CAR T-cell treatment efficacy in the presence of dexamethasone
TLDR
A mathematical model-based analysis of three patient-derived glioblastoma cell lines treated in vitro with CAR T-cells and Dexamethasone finds that in each cell line studied there is a threshold of tolerable Dexamithasone concentration, which may be used to guide the dose and timing ofCAR T-cell therapy in the presence of DexamETHasone in patients. Expand

References

SHOWING 1-10 OF 40 REFERENCES
Cellular interactions constrain tumor growth
TLDR
A statistical mechanics approach is developed that focuses on the total number of possible states each cell can occupy and shows how different assumptions on correlations of these states give rise to the many different macroscopic tumor growth laws used in the literature. Expand
Universal scaling laws rule explosive growth in human cancers.
TLDR
The discovery of universal superlinear metabolic scaling laws in human cancers are described, which underpins increasing tumour aggressiveness, due to evolutionary dynamics, which leads to an explosive growth as the disease progresses. Expand
An Evolutionary Model of Tumor Cell Kinetics and the Emergence of Molecular Heterogeneity Driving Gompertzian Growth
TLDR
The early exponential growth of the tumor and the later saturation associated with the Gompertzian curve which results from the evolutionary simulations using simple statistical mechanics principles related to the degree of functional coupling of the cell states are explained. Expand
A mean-field theory of cellular growth
We present a unified model for the growth of a population of cells. We propose that sigmoidal growth in cellular systems is a self-organised process due to long-range interactions among the cells.Expand
A revisited concept: Contact inhibition of growth. From cell biology to malignancy.
  • D. Ribatti
  • Biology, Medicine
  • Experimental cell research
  • 2017
TLDR
Not only the movement but also the proliferation of many normal cells is inhibited by cell-cell contact, and cancer cells are characteristically insensitive to such contact inhibition. Expand
A Review of Cell-Based Computational Modeling in Cancer Biology
TLDR
This review introduces the broad range of techniques available for cell-based computational modeling and illustrates these methods with examples drawn from cancer hypoxia, angiogenesis, invasion, stem cells, and immunosurveillance. Expand
Does tumor growth follow a "universal law"?
TLDR
The results support the notion that tumor growth follows such a universal law, and several important implications are discussed, including its relevance for tumor metastasis and recurrence, cell turnover rates, angiogenesis and invasion. Expand
Integrating Mathematical Modeling with High-Throughput Imaging Explains How Polyploid Populations Behave in Nutrient-Sparse Environments
TLDR
Investigation of invasion in nutrient-limiting environments inhabited by one or two cancer cell subpopulations finds ploidy as a candidate biomarker of this phenotypic heterogeneity and its potential to inform the dose of mTOR inhibitors (mTOR-I) that can inhibit chemotaxis just enough to facilitate such competition. Expand
A hybrid mathematical model of solid tumour invasion: the importance of cell adhesion.
  • A. Anderson
  • Biology, Medicine
  • Mathematical medicine and biology : a journal of the IMA
  • 2005
TLDR
A hybrid mathematical model of the invasion of healthy tissue by a solid tumour is presented and early vascular growth is considered, just after angiogenesis has occurred, to examine how the geometry of the growing tumours is affected by tumour cell heterogeneity caused by genetic mutations. Expand
Tumor growth dynamics: insights into evolutionary processes.
TLDR
A historical summary of tumor growth patterns is provided and it is argued that they can be classified into five basic categories and illustrated how those categories can provide insights into events that drive tumor progression. Expand
...
1
2
3
4
...