Shiga and Shiga-like toxins are potent bacterial cytotoxins composed of six proteins: one A-subunit that possesses a toxic N-glycosidase activity and a pentamer of identical B-subunits that anchors the toxin to glycolipids present on mammalian cells. Following their endocytosis through coated pits, a segment of the A-subunit noncovalently associated with… (More)