Local complexity of amino acid interactions in a protein core.

@article{Jain2004LocalCO,
  title={Local complexity of amino acid interactions in a protein core.},
  author={Rajul K Jain and Rama Ranganathan},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2004},
  volume={101 1},
  pages={111-6}
}
Atomic resolution structures of proteins indicate that the core is typically well packed, suggesting a densely connected network of interactions between amino acid residues. The combinatorial complexity of energetic interactions in such a network could be enormous, a problem that limits our ability to relate structure and function. Here, we report a case study of the complexity of amino acid interactions in a localized region within the core of the GFP, a particularly stable and tightly packed… CONTINUE READING