Local chromatin mobility is independent of transcriptional activity.

  title={Local chromatin mobility is independent of transcriptional activity.},
  author={Giulia Mearini and Frank O Fackelmayer},
  journal={Cell cycle},
  volume={5 17},
The dynamics of chromatin in live cells is characterized by high mobility on a sub-micrometer scale and strict constraints on larger scales. While there is ample evidence that chromatin loci can move within the nucleus in response to transcriptional activation, chromatin loci expressed at a steady state are confined to small intranuclear volumes, which they do not leave for hours. Previous work has shown, using in-vivo tagging of chromatin loci, that chromatin at the nuclear periphery has lower… CONTINUE READING