Local changes in neurosteroid levels in the substantia nigra reticulata and the ventral tegmental area alter chronic ethanol withdrawal severity in male withdrawal seizure-prone mice.

@article{Tanchuck2013LocalCI,
  title={Local changes in neurosteroid levels in the substantia nigra reticulata and the ventral tegmental area alter chronic ethanol withdrawal severity in male withdrawal seizure-prone mice.},
  author={M. Tanchuck and Debra K. Cozzoli and Ingrid He and Katherine R. Kaufman and C. Snelling and J. Crabbe and G. Mark and D. Finn},
  journal={Alcoholism, clinical and experimental research},
  year={2013},
  volume={37 5},
  pages={
          784-93
        }
}
  • M. Tanchuck, Debra K. Cozzoli, +5 authors D. Finn
  • Published 2013
  • Medicine
  • Alcoholism, clinical and experimental research
  • BACKGROUND Allopregnanolone (ALLO) is a potent positive modulator of γ-aminobutyric acidA receptors (GABAA Rs) that affects ethanol (EtOH) withdrawal. Finasteride (FIN), a 5α-reductase inhibitor that blocks the formation of ALLO and other GABAergic neurosteroids, alters EtOH sensitivity. Recently, we found that Withdrawal Seizure-Prone mice from the first genetic replicate (WSP-1) exhibited behavioral tolerance to the anticonvulsant effect of intrahippocampal ALLO during EtOH withdrawal and… CONTINUE READING
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