Local changes in lipid environment of TCR microclusters regulate membrane binding by the CD3ε cytoplasmic domain

@inproceedings{Gagnon2012LocalCI,
  title={Local changes in lipid environment of TCR microclusters regulate membrane binding by the CD3ε cytoplasmic domain},
  author={Etienne Gagnon and David A. Schubert and Susana Gordo and H. Hamlet Chu and Kai W Wucherpfennig},
  booktitle={The Journal of experimental medicine},
  year={2012}
}
The CD3ε and ζ cytoplasmic domains of the T cell receptor bind to the inner leaflet of the plasma membrane (PM), and a previous nuclear magnetic resonance structure showed that both tyrosines of the CD3ε immunoreceptor tyrosine-based activation motif partition into the bilayer. Electrostatic interactions between acidic phospholipids and clusters of basic CD3ε residues were previously shown to be essential for CD3ε and ζ membrane binding. Phosphatidylserine (PS) is the most abundant negatively… CONTINUE READING

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The cytoplasmic tail

  • L. M. Deford-Watts, T. C. Tassin, +5 authors N. S. van Oers
  • 2009
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