Local cerebral glucose utilization of the awake rat during chronic administration of nicotine.

@article{Grnwald1988LocalCG,
  title={Local cerebral glucose utilization of the awake rat during chronic administration of nicotine.},
  author={Frank Gr{\"u}nwald and Helmut Schroeck and H Theilen and Anton Biber and Wolfgang Kuschinsky},
  journal={Brain research},
  year={1988},
  volume={456 2},
  pages={350-6}
}
Local cerebral glucose utilization (LCGU) was measured in 45 regions of the rat brain during chronic nicotine infusion using the quantitative autoradiographic 2-deoxy-D-[1-14C]glucose method described by Sokoloff et al. [J. Neurochem., 28 (1977) 897-916]. Osmotic minipumps, filled with L-nicotine, were implanted 14 days before the measurement of LCGU. The infused nicotine dose of 12.5 micrograms/kg/min resulted in a plasma nicotine concentration of 77 +/- 17 and a plasma cotinine concentration… CONTINUE READING