Local calcium-dependent mechanisms determine whether a cut axonal end assembles a retarded endbulb or competent growth cone.

@article{Kamber2009LocalCM,
  title={Local calcium-dependent mechanisms determine whether a cut axonal end assembles a retarded endbulb or competent growth cone.},
  author={Dotan Kamber and Hadas Erez and Micha E. Spira},
  journal={Experimental neurology},
  year={2009},
  volume={219 1},
  pages={112-25}
}
The transformation of a cut axonal end into a growth cone (GC), after axotomy, is a critical event in the cascade leading to regeneration. In an earlier series of studies we analyzed the cellular cascades that transform a cut axonal end into a competent GC. We found that axotomy of cultured Aplysia neurons leads to a transient elevation of the free intracellular Ca2+ concentration ([Ca2+]i), calpain activation and localized proteolysis of submembranal spectrin. These events are associated with… CONTINUE READING

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