Local axonal trajectories in mouse barrel cortex

  title={Local axonal trajectories in mouse barrel cortex},
  author={Kerry L. Bernardo and J. S. McCasland and Thomas A. Woolsey},
  journal={Experimental Brain Research},
SummaryQuantitative studies were made of the distribution of labeled intracortical axons after focal injections of horseradish peroxidase (HRP) into mouse barrel cortex, in vitro. The pattern of labeled fibers was compared to that of labeled cell bodies with respect to the barrel map in layer IV. We analyzed 4 cortices with injections in supragranular layers and centered above a single barrel row. Computer microscope/image analysis routines were used to collect the data and to perform various… 
Sensorimotor corticocortical projections from rat barrel cortex have an anisotropic organization that facilitates integration of inputs from whiskers in the same row
Results indicate that SI projections to MI and SII have an anisotropic organization that facilitates the integration of sensory information received from neighboring barrels that represent whiskers in the same row.
Glutamate receptor blockade alters the development of intracortical connections in rat barrel cortex
Glutamate receptor blockade did not prevent the growth of intrinsic projections, but altered their organization, and the normal row-like asymmetry of connections in untreated hemispheres was lacking in the D-AP5 treated cortex.
Differential response patterns in the si barrel and septal compartments during mechanical whisker stimulation.
A growing body of evidence suggests that the barrel and septal regions in layer IV of rat primary somatosensory (SI) cortex may represent separate processing channels. To assess this view, pairs of
The Origin of Cortical Surround Receptive Fields Studied in the Barrel Cortex
It is demonstrated that the surround receptive fields of barrel cells are generated by intracortical transmission and that many septal cells derive a component of their surround receptive field from the thalamus.
Somatosensory cortical input to the striatum
The anatomical study revealed that GABAergic intemeurones receive convergent cortical input from both motor and sensory cortices and that their pattern of innervation is different from the cortical innervation of striatal output.
Voltage-sensitive dye imaging reveals shifting spatiotemporal spread of whisker-induced activity in rat barrel cortex.
Surprisingly, a spatial shift in the center of activation occurring over a 10- to 20-ms period with shift magnitudes of 1-2 barrels is observed within the barrel field and is suggested to provide an important insight for understanding barrel field activation during whisking behavior.
Unimodal primary sensory cortices are directly connected by long-range horizontal projections in the rat sensory cortex
It is suggested that diffuse, border-crossing axonal projections connecting directly primary cortices are an important organizational motif common to all major primary sensory cortices in the rat.
Monosynaptic connections between pairs of L5A pyramidal neurons in columns of juvenile rat somatosensory cortex.
Paired recordings probed the anatomy and physiology of monosynaptic connections between L5A pyramidal neurons within the barrel columns of somatosensory cortex in acute slices of approximately 3-week-old rats to suggest a mechanism of feed-forward excitation by which synchronized single action potentials are efficiently transmitted.
Peripheral Deafferentation-Driven Functional Somatosensory Map Shifts Are Associated with Local, Not Large-Scale Dendritic Structural Plasticity
The data suggest that peripheral nerve lesion-induced cortical map shifts do not depend on the large scale restructuring of dendritic arbors but are rather associated with local cell-type and position-dependent changes in dendrite synaptic connectivity.
Stimulus-induced intercolumnar synchronization of neuronal activity in rat barrel cortex: a laminar analysis.
Although infragranular neuron pairs displayed similar amounts of synchronization in response to each stimulus frequency, granular and supragranular neurons were synchronized mainly during stimulation at 2 or 5 Hz, suggesting that neuronal synchronization plays an important role in transmitting sensory information to other cortical or subcortical brain regions.


Computer‐assisted analyses of barrel neuron axons and their putative synaptic contacts
The “barrels” in layer IV of rodent SmI neocortex receive inputs from individual whiskers on the contralateral face and the axons of these cells were examined and the locations of close appositions to dendrites of other impregnated neurons were mapped.
Organization of the projections from barrel cortex to thalamus in mice studied with Phaseolus vulgaris-leucoagglutinin and HRP
It was concluded that the corticothalamic projections originating from one barrel column contact an arc of barreloids in VB, which is discretely and topographically organized.
Organization of feedback and feedforward projections of the barrel cortex: a PHA-L study in the mouse
The organization of the efferents from the barrel cortex demonstrates a contrast between feedback and feedforward projections from this important area of neocortex.
Structure of layer IV in the somatosensory neocortex of the rat: Description and comparison with the mouse
The posteromedial barrel subfield in the rat is a special region of the barrel field in which the barrels are arranged in five rows and are larger than elsewhere and are filled with small neurons nearly throughout the thickness of layer IV.
High‐resolution 2‐deoxyglucose mapping of functional cortical columns in mouse barrel cortex
Cortical columns associated with barrels in layer IV of the somatosensory cortex were characterized by high‐resolution 2‐deoxy‐D‐glucose (2DG) autoradiography in freely behaving mice. The method
Local intra‐ and interlaminar connections in mouse barrel cortex
Focal injections of horseradish peroxidase in dimethylsulfoxide were targeted into mouse somatosensory cortex, in vitro, with a template to determine quantitative connectivity patterns within and between barrel‐defined cortical columns.
Organization of corticocortical connections in the parietal cortex of the rat
An analysis based on Nissl, anterograde degeneration, and sucinic dehydrogenase histochemical techniques reveals that there are two distinct regions of parietal cortex which are characterized by
Functional organization of mouse and rat SmI barrel cortex following vibrissal damage on different postnatal days.
The data indicate that neonatal damage to the whiskers alters both the anatomical arrangement of the barrels and the physiologically determined somatotopic representation of the sensory periphery in a parallel and predictable fashion.
Organization of corticocortical connections in human visual cortex.
The results show that the connections in human visual cortex are similar to those of nonhuman primates and that their organization is consistent with the concept of multiple processing streams in the visual system.
Thalamocortical response transformation in the rat vibrissa/barrel system.
A cyclic pattern of stimulus-evoked excitation/inhibition characterizes responses in the cortical barrels but is considerably less pronounced in the thalamic barreloids.