Local applications but global implications: Can pesticides drive microorganisms to develop antimicrobial resistance?

  title={Local applications but global implications: Can pesticides drive microorganisms to develop antimicrobial resistance?},
  author={Balasubramanian Ramakrishnan and Kadiyala Venkateswarlu and Nambrattil Sethunathan and Mallavarapu Megharaj},
  journal={The Science of the total environment},

Influence of Abiotic Factors in the Emergence of Antibiotic Resistance

The ecosystem is continuously exposed to a wide variety of chemicals and antimicrobials, which act as a source for the spread of ARGs, and several recent investigations have helped to understand the dynamic environmental factors in the spread.

Contribution of insect gut microbiota and their associated enzymes in insect physiology and biodegradation of pesticides

This review summarizes the toxic effects of agrochemicals on humans, animals, birds and beneficial arthropods and explores the preferential role of insect gut microbial species in the degradation process and the resistance mechanism of several pesticides in insect species.

From environment to clinic: the role of pesticides in antimicrobial resistance

Pesticides are examined as mediators for the appearance of AMR, and as a route for antibiotic resistance genes and antimicrobial resistant bacteria to the anthropic environment.

Deteriorating microbiomes in agriculture - the unintended effects of pesticides on microbial life

Current evidence suggests that immediate action is needed by regulatory authorities in amending safety assessments for “non-antimicrobial” pesticides; and that the development of host-free microbiome model systems could be useful for rapidly screening pesticides against functionally distinct microbial catalogues of interest.

Insight into the impacts and mechanisms of ketone stress on the antibiotic resistance in Escherichia coli

Findings provided the first evidence for the evolution of bacterial resistance in response to ketone organics in E. coli.

A Glyphosate-Based Herbicide Cross-Selects for Antibiotic Resistance Genes in Bacterioplankton Communities

A freshwater mesocosm experiment showing that a GBH strongly selects for ARGs, particularly multidrug efflux pumps, indicates that GBHs can cross-select for antibiotic resistance in natural freshwater bacteria.

Exposure to environmental stress decreases the resistance of river microbial communities towards invasion by antimicrobial resistant bacteria

Environmental microbiomes are constantly exposed to invasion events through foreign, antibiotic resistant bacteria that were enriched in the anthropic sphere. However, the biotic and abiotic factors,



Novel Antibiotic Resistance Determinants from Agricultural Soil Exposed to Antibiotics Widely Used in Human Medicine and Animal Farming

The discovery of several previously unknown antibiotic resistance genes from uncultured soil microorganisms indicates that soil is a significant reservoir of resistance determinants, which, once acquired and “repurposed” by pathogenic bacteria, can have serious impacts on therapeutic outcomes.

The Rising Tide of Antimicrobial Resistance in Aquaculture: Sources, Sinks and Solutions

As the human population increases there is an increasing reliance on aquaculture to supply a safe, reliable, and economic supply of food, and it is essential that the sources and sinks of antimicrobial resistance are identified and monitored, in order to better understand the implications to human and environmental health.

Bacterial biodegradation of neonicotinoid pesticides in soil and water systems.

This review focuses on the biodegradation of neonicotinoid-mineralising bacterial strains in soil and water systems by the bacterial community and indicates that enhanced biotransformation of these pesticides can be accomplished by mixed microbial populations under optimised environmental conditions.

Bacterial Chemotaxis toward Environmental Pollutants: Role in Bioremediation

Recent discoveries in bacterial chemotaxis toward pollutants are described and how they may be explored and exploited for bioremediation applications are described.

Bloom of resident antibiotic-resistant bacteria in soil following manure fertilization

It is found that dairy cow manure amendment enhanced the proliferation of resident antibiotic-resistant bacteria and genes encoding β-lactamases in soil even though the cows from which the manure was derived had not been treated with antibiotics.

The evolution of new enzyme function: lessons from xenobiotic metabolizing bacteria versus insecticide-resistant insects

The evolutionary routes by which bacteria and insects have evolved enzymatic processes for the degradation of four classes of synthetic chemical insecticide support recent theory proposing that new biochemical functions often evolve from ‘promiscuous' activities in existing enzymes, with subsequent mutations then enhancing those activities.

Fertilizing with Animal Manure Disseminates Antibiotic Resistance Genes to the Farm Environment.

This study shows that antibiotic resistance genes are disseminated on Finnish production animal farms, and the spreading of resistance genes in farm-associated environments could possibly be limited by experimenting with new manure handling methods that could reduce the abundance of the genes in manure used for land application.

Antibiotics in Agroecosystems: Introduction to the Special Section.

This introduction summarizes the current state of science for analyzing antibiotics and antibiotic resistance in agroecosystems, discusses current knowledge gaps, and develops future research priorities.