Local application of the endocannabinoid hydrolysis inhibitor URB597 reduces nociception in spontaneous and chemically induced models of osteoarthritis.

@article{Schuelert2011LocalAO,
  title={Local application of the endocannabinoid hydrolysis inhibitor URB597 reduces nociception in spontaneous and chemically induced models of osteoarthritis.},
  author={Niklas Schuelert and Michael P. Johnson and Jennifer L Oskins and Karandeep Jassal and Mark G Chambers and Jason J McDougall},
  journal={Pain},
  year={2011},
  volume={152 5},
  pages={975-81}
}
The present study examined whether enhancement of endogenous cannabinoid levels by administration of the fatty acid amide hydrolase inhibitor URB597 could modulate joint nociception in 2 rodent models of osteoarthritis (OA). OA-like changes were induced in male Wistar rats by intra-articular injection of monoiodoacetate, while Dunkin-Hartley guinea pigs (age 9-12 months) develop OA naturally and were used as a model of spontaneous OA. Joint nociception was measured by recording… CONTINUE READING
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A brief history of cannabinoid and endocannabinoid pharmacology as inspired by the work of British scientists

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