Local application of drugs to study nicotinic acetylcholine receptor function in mouse brain slices.

@article{Engle2012LocalAO,
  title={Local application of drugs to study nicotinic acetylcholine receptor function in mouse brain slices.},
  author={Staci E Engle and Hilary J Broderick and Ryan M Drenan},
  journal={Journal of visualized experiments : JoVE},
  year={2012},
  volume={68},
  pages={e50034}
}
Tobacco use leads to numerous health problems, including cancer, heart disease, emphysema, and stroke. Addiction to cigarette smoking is a prevalent neuropsychiatric disorder that stems from the biophysical and cellular actions of nicotine on nicotinic acetylcholine receptors (nAChRs) throughout the central nervous system. Understanding the various nAChR subtypes that exist in brain areas relevant to nicotine addiction is a major priority. Experiments that employ electrophysiology techniques… CONTINUE READING
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