Local antigen in nonlymphoid tissue promotes resident memory CD8+ T cell formation during viral infection

@inproceedings{Khan2016LocalAI,
  title={Local antigen in nonlymphoid tissue promotes resident memory CD8+ T cell formation during viral infection},
  author={Tahsin N. Khan and Jana L Mooster and Augustus M Kilgore and Jossef F Osborn and Jeffrey C Nolz},
  booktitle={The Journal of experimental medicine},
  year={2016}
}
Tissue-resident memory (Trm) CD8(+) T cells are functionally distinct from their circulating counterparts and are potent mediators of host protection against reinfection. Whether local recognition of antigen in nonlymphoid tissues during infection can impact the formation of Trm populations remains unresolved. Using skin infections with vaccinia virus (VacV)-expressing model antigens, we found that local antigen recognition had a profound impact on Trm formation. Activated CD8(+) T cells… CONTINUE READING
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