Local anesthetics and divalent cations have the same effect on the headgroups of phosphatidylcholine and phosphatidylethanolamine.

Abstract

The effects of the local anesthetic dibucaine on the membrane headgroup conformations of phosphatidylcholine and phosphatidylethanolamine were determined using 2H- and 31P-NMR. The size of the deuterium quadrupole splittings of the two methylene segments of the choline and ethanolamine groups changed dramatically and the 31-phosphorus chemical shift… (More)

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