Local anesthetics QX 572 and benzocaine act at separate sites on the batrachotoxin-activated sodium channel

Abstract

We have studied the effect of local anesthetics QX 572, which is permanently charged, and benzocaine, which is neutral, on batrachotoxin-activated sodium channels in mouse neuroblastoma N18 cells. The dose-response curves for each drug suggest that QX 752 and benzocaine each act on a single class of binding sites. The dissociation constants are 3.15 X 10(-5… (More)

Topics

4 Figures and Tables

Slides referencing similar topics