Local anesthetics: hydrophilic and hydrophobic pathways for the drug- receptor reaction

  title={Local anesthetics: hydrophilic and hydrophobic pathways for the drug- receptor reaction},
  author={B. Hille},
  journal={The Journal of General Physiology},
  pages={497 - 515}
  • B. Hille
  • Published 1977
  • Chemistry, Medicine
  • The Journal of General Physiology
  • The properties of Na channels of the node of Ranvier are altered by neutral, amine, and quaternary local anesthetic compounds. The kinetics of the Na currents are governed by a composite of voltage- and time- dependent gating processes with voltage- and time-dependent block of channels by drug. Conventional measurements of steady-state sodium inactivation by use of 50-ms prepulses show a large negative voltage shift of the inactivation curve with neutral benzocaine and with some ionizable… CONTINUE READING

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    Publications referenced by this paper.
    The action of calcium and of local anesthetics on nerve cells, and their interaction during excitation.
    • 61