Local anesthetic properties of prenylamine.

@article{Mujtaba2001LocalAP,
  title={Local anesthetic properties of prenylamine.},
  author={Mustafa G Mujtaba and Peter Gerner and G. K. Wang},
  journal={Anesthesiology},
  year={2001},
  volume={95 5},
  pages={1198-204}
}
BACKGROUND Local anesthetics that produce analgesia of long duration with minimal impairment of autonomic functions are highly desirable for pain management in the clinic. Prenylamine is a known calcium channel blocker, but its local anesthetic blocking effects on voltage-gated sodium channels have not been studied thus far. METHODS The authors characterized the tonic and use-dependent prenylamine block of native Na(+) channels in cultured rat neuronal GH3 cells during whole cell voltage… CONTINUE READING
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