Local anesthetic block of batrachotoxin-resistant muscle Na+ channels.

  title={Local anesthetic block of batrachotoxin-resistant muscle Na+ channels.},
  author={G. K. Wang and Catherine Quan and S. Y. Wang},
  journal={Molecular pharmacology},
  volume={54 2},
Local anesthetics (LAs) are noncompetitive antagonists of batrachotoxin (BTX) in voltage-gated Na+ channels. The putative LA receptor has been delineated within the transmembrane segment S6 in domain IV of voltage-gated Na+ channels, whereas the putative BTX receptor is within segment S6 in domain I. In this study, we created BTX-resistant muscle Na+ channels at segment I-S6 (micro1-N434K, micro1-L437K) to test whether these residues modulate LA binding. These mutant channels were expressed in… CONTINUE READING
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A mutation in segment I-S6 alters slow inactivation of sodium channels

  • Wang S-Y, GK Wang
  • Biophys J 72:1633–1640
  • 1997

Local anesthetics, in Goodman & Gilman’s: The Pharmacological Basis of Therapeutics (Hardman JG, Limbird LE, Molinoff PB

  • WA Catterall, K Mackie
  • Ruddon RW, Gilman AG,
  • 1996
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