Local anesthetic action of carboxylic esters: Evidence for the significance of molecular volume and for the number of sites involved


The effects of the homologous series of carboxylic esters, methyl propionate to methyl decanoate, on the steadystate inactivation of the sodium current in squid axons have been studied. The esters moved the relationship between the inactivation parameter,h ∞, and the membrane potential in the hyperpolarizing direction, thus reducing the number of sodium… (More)
DOI: 10.1007/BF01869159

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