Local and systemic toxicity of intravitreal melphalan for vitreous seeding in retinoblastoma: a preclinical and clinical study.

@article{Francis2014LocalAS,
  title={Local and systemic toxicity of intravitreal melphalan for vitreous seeding in retinoblastoma: a preclinical and clinical study.},
  author={Jasmine H Francis and Paula Schaiquevich and Emiliano Buitrago and Mar{\'i}a Jos{\'e} Del Sole and Gustavo L Zapata and J Oscar Croxatto and Brian P F Marr and Scott E Brodie and Alejandro Berra and Guillermo L Chantada and David H Abramson},
  journal={Ophthalmology},
  year={2014},
  volume={121 9},
  pages={1810-7}
}
PURPOSE Intravitreal melphalan is emerging as an effective treatment for refractory vitreous seeds in retinoblastoma, but there is limited understanding regarding its toxicity. This study evaluates the retinal and systemic toxicity of intravitreal melphalan in retinoblastoma patients, with preclinical validation in a rabbit model. DESIGN Clinical and… CONTINUE READING