We have tested whether two local anaesthetics, in the lumen of cat trachea in vivo, would block the stimulation of mucus secretion by parasympathetic nerves without altering its stimulation by a cholinergic drug. Lignocaine, 4.3-43 mM (0.1-1%) in Krebs-Henseleit, increased the output of mucus macromolecules. It abolished secretion in response to vagus nerve… (More)
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