Local amplification of platelet function by 8-Epi prostaglandin F2alpha is not mediated by thromboxane receptor isoforms.

@article{Pratic1996LocalAO,
  title={Local amplification of platelet function by 8-Epi prostaglandin F2alpha is not mediated by thromboxane receptor isoforms.},
  author={Domenico Pratic{\`o} and Emer M. Smyth and Francesco Violi and Garret A. FitzGerald},
  journal={The Journal of biological chemistry},
  year={1996},
  volume={271 25},
  pages={14916-24}
}
8-epi-Prostaglandin (PG) F2alpha may be formed by cyclooxygenases 1 and 2 or by a free radical catalyzed process as an isoprostane. Concentrations of 8-epi-PGF2alpha in the range 1 nM to 1 microM induce a dose-dependent increase in platelet shape change, in calcium release from intracellular stores [Ca2+]iand in inositol phosphates; it also causes irreversible platelet aggregation, dependent on thromboxane generation, when incubated with subthreshold concentrations of ADP, thrombin, collagen… CONTINUE READING

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