Local allergic rhinitis: a new entity, characterization and further studies

@article{Rondn2010LocalAR,
  title={Local allergic rhinitis: a new entity, characterization and further studies},
  author={Carmen Rond{\'o}n and Gabriela Cant{\'o} and Miguel Blanca},
  journal={Current Opinion in Allergy and Clinical Immunology},
  year={2010},
  volume={10},
  pages={1–7}
}
Purpose of reviewThe purpose of this review is to describe new insights into the pathophysiology and clinical characterization of ‘local allergic rhinitis’, a new phenotype of rhinitis that may affect individuals previously diagnosed with nonallergic rhinitis. Recent findingsSeveral studies have shown the existence of local allergic rhinitis with nasal production of specific IgE (sIgE) antibodies in the absence of atopy in over 40% of nonallergic rhinitis patients. Evidence for this entity is… 
Local allergic rhinitis: concept, clinical manifestations, and diagnostic approach.
TLDR
An advanced diagnostic approach is proposed in patients with symptoms suggestive of allergic rhinitis but negative results in skin prick test and serum slgE determination, and a positive nasal allergen provocation test with local production of tryptase, ECP, and slg eosinophil cationic protein are useful.
Local allergic rhinitis: evolution of concepts
TLDR
The combination of IgE detection in nasal mucosa and a positive result of NPT should be used to diagnose local allergic rhinitis, and an appraisal of the basophil activation test as a third level technique, when the results of local IgE testing and NPT are uncertain.
Local allergic rhinitis: Implications for management
TLDR
Several recent studies support the effectiveness and safety of allergen immunotherapy for LAR, which opens a window of treatment opportunity in patients with symptoms suggestive of AR but no evidence of systemic atopy.
Local allergic rhinitis: A critical reappraisal from a paediatric perspective
TLDR
The purpose of this ‘Rostrum’ was to critically discuss data and implications of the ‘LAR concept’ in paediatrics, and suggest also the hypothetical role of allergen immunoprophylaxis or immunotherapy in LAR.
Is the evidence of local allergic rhinitis growing?
TLDR
Diagnosis of LAR is crucial in order to start an etiologic treatment such as allergen immunotherapy, which has proven to be very effective in these patients.
Local Allergic Rhinitis Revisited
TLDR
This review aims to comprehensively summarize the current knowledge on LAR and address unmet needs in the areas of disease diagnosis and treatment.
Local Allergic Rhinitis: Is There a Role for Systemic Allergy Immunotherapy?
TLDR
Subcutaneous allergen-specific immunotherapy for grass pollen and Dermatophagoides pteronyssinus has been demonstrated in adults with LAR, a new phenotype of allergic rhinitis characterized by the presence of a localized allergic response in the nasal mucosa with negative skin tests and no detection of serum-specific IgE antibodies in the peripheral blood.
[Local allergic rhinitis].
TLDR
D diagnosis of local allergic rhinitis is made using nasal allergen provocation tests when the prick test for standard inhalation allergens (SIA) and the serum specific IgE analysis for aeroallergens are negative.
Seasonal Local Allergic Rhinitis in Areas With High Concentrations of Grass Pollen.
TLDR
LAR to grass pollen is relevant in patients with seasonal symptoms indicative of allergic rhinitis but with a negative skin test result who live in areas with high allergenic pollen loads, and should be included in the differential diagnosis ofrhinitis.
Local Allergic Rhinitis.
TLDR
Recent studies have demonstrated that allergen immunotherapy is an effective immune-modifying treatment, highlighting the importance of early diagnosis of local allergic rhinitis.
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References

SHOWING 1-10 OF 69 REFERENCES
Local IgE production and positive nasal provocation test in patients with persistent nonallergic rhinitis.
TLDR
The hypothesis that in persistent nonallergic rhinitis some patients may have local inflammation, nasal IgE production, and a positive response to a nasal allergen provocation test despite no evidence of systemic atopy is supported.
Nasal inflammatory mediators and specific IgE production after nasal challenge with grass pollen in local allergic rhinitis.
TLDR
It is demonstrated that patients with LAR had local production of sIgE and mast cell/eosinophil activation induced by nasal exposure to grass pollen in response to NAPT with grass pollen.
Evolution of patients with nonallergic rhinitis supports conversion to allergic rhinitis.
TLDR
Persistent moderate-to-severe rhinitis associated with asthma, conjunctivitis, or both and sensitization to aeroallergens are likely to appear at a later date in adults initially given diagnoses of NAR and a periodic re-evaluation of these patients might therefore be necessary.
Mechanisms and mediators of nasal symptoms in non‐allergic rhinitis
TLDR
Symptoms of nasal congestion and rhinorrhoea tend to be more prominent and persistent in non‐allergic rhinitic patients compared with allergic rhinitis, and the underlying pathophysiological basis should enable the development of more accurate testing, and better targeted therapeutic options in the future.
Idiopathic rhinitis, the ongoing quest
TLDR
The currently known causes for nonallergic noninfectious rhinitis and possible treatments are summarized and possible pathophysiological mechanisms of IR are discussed.
Seasonal non-allergic rhinitis (SNAR)--a new disease entity? A clinical and immunological comparison between SNAR, seasonal allergic rhinitis and persistent non-allergic rhinitis.
TLDR
SNAR seems to be different from SAR and PNAR regarding immunological mechanism and symptom period, and it is concluded that the cause of SNAR is unknown.
Nonallergic rhinitis with eosinophilia (NARES syndrome). Clinical and immunologic presentation.
TLDR
A characteristic pattern of symptomatic presentation and a paucity of the in vivo and in vitro findings associated with IgE-mediated nasal disease distinguishes this homogeneous disorder from perennial allergic rhinitis.
Tryptase levels in nasal-lavage fluid as an indicator of the immediate allergic response.
TLDR
Tryptase levels in nasal-lavage fluid appear promising as a useful indicator of allergic reactions and indicate that mast cell activation is the major factor in the immediate nasal-allergic response.
Seasonal idiopathic rhinitis with local inflammatory response and specific IgE in absence of systemic response
TLDR
N nasal mucosa inflammation, the presence of nasal specific‐IgE and the response to nasal allergen provocation test (NAPT) in patients with seasonal IR who presented symptoms only in spring are examined.
LOCAL PRODUCTION OF SPECIFIC IgE ANTIBODIES IN ALLERGIC-RHINITIS PATIENTS WITH NEGATIVE SKIN TESTS
TLDR
A group of patients with allergic rhinitis had a clinical history strongly suggestive of house-dust-mite allergy but negative skin reactions when prick tested with D. pteronyssinus extracts, indicating that these patients had allergicrhinitis mediated by the local production of IgE antibodies.
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