Local administration of WP9QY (W9) peptide promotes bone formation in a rat femur delayed-union model

@article{Sawa2017LocalAO,
  title={Local administration of WP9QY (W9) peptide promotes bone formation in a rat femur delayed-union model},
  author={Mikiya Sawa and Shigeyuki Wakitani and Naosuke Kamei and Shinji Kotaka and Nobuo Adachi and Mitsuo Ochi},
  journal={Journal of Bone and Mineral Metabolism},
  year={2017},
  volume={36},
  pages={383-391}
}
The WP9QY peptide (W9) consists of nine amino acids. It binds to RANKL and blocks RANKL-induced increases in bone resorption and osteoclastogenesis. W9 has a unique effect on the coupling mechanism between osteoclasts and osteoblasts, which promotes bone formation while working to suppress bone resorption. In this study, with the aim of clinical application of W9 for fracture treatment, we aimed to clarify the bone repair-promoting effect of W9 when administered locally to a rat femur model of… 
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